L'identité urbaine d'al-Hudayyda sous la seconde occupation ottomane, 1849-1918

Little fishing harbor on the Red Sea coast, al-Hudayyda's status and dimension progressively change with the arrival of the Ottoman army in 1839. The town is then chosen as one of the strategic points (military and political) of the Ottoman colonial system. Thanks to the various infrastructures set up by the Ottoman administration, but thanks also to the opening of Suez Canal in 1869, al-Hudayyda slowly attracts a multiethnic and cosmopolitan population: a part of it having come for trading aims, another part just taking refuge in the town, the political context being quiet unsettled in the area. Having just a little hundred inhabitants originally, al-Hudayyda's population grows to 42 000 people on the verge of World War I. Is the cohabitation under the Ottoman administration going to generate exchanges or borrowings between the various communities or not? Are the Ottomans going to manage the transcending of the many identity belongings in order to create an “Empire citizenship”, as it is planned in their ambitious reform programme? Will al-Hudayyda be endowed with a specific identity strong enough to make people of various communities identify themselves with the town? These are some of the questions which this article tries to answer.Petit port de pêche situé sur les côtes de la mer Rouge, al-/Hudayyda change progressivement de statut et de dimensions avec l'arrivée de l'armée ottomane en 1839. Al-/Hudayyda se voit alors choisi comme l'un des points stratégiques (militaire et politique) du dispositif colonial ottoman. Grâce aux différentes infrastructures mises en place par l'administration ottomane, mais aussi grâce à l'ouverture du canal de Suez en 1869, le village attire peu à peu une population multiethnique et cosmopolite venue y commercer ou simplement y trouver refuge, dans un contexte politique régional passablement agité. D'une centaine de yéménites à l'origine, il compte 42 000 âmes à la veille de la première guerre mondiale. La cohabitation sous administration ottomane va-t-elle générer ou non des échanges ou emprunts entre les différentes communautés ? Les Ottomans vont-ils réussir à transcender les multiples appartenances identitaires au profit d'une appartenance citoyenne à l'empire, comme le prévoit leur ambitieux programme de réformes ? La ville d'al-/Hudayyda sera-t-elle dotée d'une identité spécifique suffisamment forte pour que les individus appartenant aux différentes communautés présentes s'identifient à la ville ? Voilà quelques unes des questions auxquelles cet article tente de répondre

Mémoire organisationnelle adaptative en vue d'une classification automatique pour la capitalisation d'informations

International audienceUne mémoire organisationnelle est un espace de capitalisation d’informations diverses circulant au sein d’une entreprise. L’objectif de nos travaux est d’assister les usagers dans le classement de ces informations au sein de cette mémoire organisationnelle tout en limitant leur contribution. Pour ce faire, nous proposons un méta-modèle de mémoire organisationnelle sur lequel nous souhaitons faire reposer un processus de classification automatique

Organizational memory: A model based on a heterogeneous network and an automatic information integration process

Organizational memory is a space where various information circulating in a company are capitalized. From the users' point of view, an organizational memory, which can be seen as an information system component, is very important since it stores the “shared knowledge” of the organization. But, at the same time, the cost of this knowledge is relatively high since users' participation, i.e. to integrate/maintain... the memory is important. The aim of our work is to model an organizational memory through a heterogeneous network on which is based an automatic information integration process to assist users in this task while limiting their effort. We developed a prototype and evaluated through an experiment its ability to integrate new information into an organizational memory based on the proposed model

Influence of the gun barrel straightness on projectile exit conditions

Gun accuracy is influenced by several parameters during the internal ballistics phase. Accuracy is defined by the bias and dispersion of impact points on the target. The aim of this study is to determine the influence of gun barrel straightness on projectile exit conditions, in order to understand how to improve weapon accuracy. A numerical firing analysis was carried out with LS-Dyna software. The model validity is proven by its ability to accurately predict the measured circumferential strains caused by the forcing effect of the projectile, and by the consistency of the contact forces at the projectile-tube interface. To validate the firing simulation, circumferential strains of the tube were measured and compared to LS-Dyna results. Subsequently, the barrel geometry was modified to add a straightness defect to the initial curvature due to gravity. Lastly, a post-treatment was performed to determine the angular and transverse velocities of the projectile during internal ballistics phase. This analysis shown the influence of specific shapes on ammunition balloting and velocity

A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation

Bioinformatic analysis of the intergenic regions of Staphylococcus aureus predicted multiple regulatory regions. From this analysis, we characterized 11 novel noncoding RNAs (RsaA‐K) that are expressed in several S. aureus strains under different experimental conditions. Many of them accumulate in the late-exponential phase of growth. All ncRNAs are stable and their expression is Hfq-independent. The transcription of several of them is regulated by the alternative sigma B factor (RsaA, D and F) while the expression of RsaE is agrA-dependent. Six of these ncRNAs are specific to S. aureus, four are conserved in other Staphylococci, and RsaE is also present in Bacillaceae. Transcriptomic and proteomic analysis indicated that RsaE regulates the synthesis of proteins involved in various metabolic pathways. Phylogenetic analysis combined with RNA structure probing, searches for RsaE‐mRNA base pairing, and toeprinting assays indicate that a conserved and unpaired UCCC sequence motif of RsaE binds to target mRNAs and prevents the formation of the ribosomal initiation complex. This study unexpectedly shows that most of the novel ncRNAs carry the conserved C−rich motif, suggesting that they are members of a class of ncRNAs that target mRNAs by a shared mechanis

Long-term outcomes after reduced-intensity conditioning allogeneic stem cell transplantation for low-grade lymphoma: a survey by the French Society of Bone Marrow Graft Transplantation and Cellular Therapy (SFGM-TC).

International audienceBACKGROUND AND OBJECTIVES: High-dose chemotherapy with allogeneic stem cell transplantation (SCT) has proven to be a successful treatment for low-grade lymphoma (LGL), but is associated with considerable transplant-related mortality (TRM). In an effort to reduce toxic mortality while maintaining the graft-versus-leukemia effect, allogeneic SCT has been combined with a reduced-intensity conditioning (RIC) regimen. The aim of this study was to determine the outcome of patients with LGL treated with RIC allogeneic SCT. DESIGN AND METHODS: This retrospective multicenter study included 73 patients with relapsed or refractory LGL allografted after a RIC regimen between 1998 and 2005 whose data were recorded in a French registry. RESULTS: Patients received a median of three lines of therapy prior to RIC allogeneic SCT. The most widely used conditioning regimens were fludarabine + busulfan + antithymocyte globulin (n=43) and fludarabine + total body irradiation (n=21). Prior to allografting, patients were in complete response (CR; n=21), partial response (PR; n=33) or had chemoresistant disease (n=19). The median follow-up was 37 months (range, 16 to 77 months). In patients in CR, PR and chemoresistant disease, the 3-year overall survival rates were 66%, 64% and 32%, respectively, while the 3-year event-free survival rates were 66%, 52% and 32%, respectively. The 3-year cumulative incidences of TRM were 32%, 28% and 63%, respectively. The incidence of relapse was 9.6%. INTERPRETATION AND CONCLUSIONS: Although associated with significant TRM, RIC allogeneic SCT in advanced chemosensitive disease leads to long-term survival

HST-COS Observations of Hydrogen, Helium, Carbon and Nitrogen Emission from the SN 1987A Reverse Shock

We present the most sensitive ultraviolet observations of Supernova 1987A to date. Imaging spectroscopy from the Hubble Space Telescope-Cosmic Origins Spectrograph shows many narrow (dv \sim 300 km/s) emission lines from the circumstellar ring, broad (dv \sim 10 -- 20 x 10^3 km/s) emission lines from the reverse shock, and ultraviolet continuum emission. The high signal-to-noise (> 40 per resolution element) broad LyA emission is excited by soft X-ray and EUV heating of mostly neutral gas in the circumstellar ring and outer supernova debris. The ultraviolet continuum at \lambda > 1350A can be explained by HI 2-photon emission from the same region. We confirm our earlier, tentative detection of NV \lambda 1240 emission from the reverse shock and we present the first detections of broad HeII \lambda1640, CIV \lambda1550, and NIV] \lambda1486 emission lines from the reverse shock. The helium abundance in the high-velocity material is He/H = 0.14 +/- 0.06. The NV/H-alpha line ratio requires partial ion-electron equilibration (T_{e}/T_{p} \approx 0.14 - 0.35). We find that the N/C abundance ratio in the gas crossing the reverse shock is significantly higher than that in the circumstellar ring, a result that may be attributed to chemical stratification in the outer envelope of the supernova progenitor. The N/C abundance ratio may have been stratified prior to the ring expulsion, or this result may indicate continued CNO processing in the progenitor subsequent to the expulsion of the circumstellar ring.Comment: 12 pages, 8 figures. ApJ - accepte

ILC2-modulated T cell-to-MDSC balance is associated with bladder cancer recurrence.

Non-muscle-invasive bladder cancer (NMIBC) is a highly recurrent tumor despite intravesical immunotherapy instillation with the bacillus Calmette-Guérin (BCG) vaccine. In a prospective longitudinal study, we took advantage of BCG instillations, which increase local immune infiltration, to characterize immune cell populations in the urine of patients with NMIBC as a surrogate for the bladder tumor microenvironment. We observed an infiltration of neutrophils, T cells, monocytic myeloid-derived suppressor cells (M-MDSCs), and group 2 innate lymphoid cells (ILC2). Notably, patients with a T cell-to-MDSC ratio of less than 1 showed dramatically lower recurrence-free survival than did patients with a ratio of greater than 1. Analysis of early and later time points indicated that this patient dichotomy existed prior to BCG treatment. ILC2 frequency was associated with detectable IL-13 in the urine and correlated with the level of recruited M-MDSCs, which highly expressed IL-13 receptor α1. In vitro, ILC2 were increased and potently expressed IL-13 in the presence of BCG or tumor cells. IL-13 induced the preferential recruitment and suppressive function of monocytes. Thus, the T cell-to-MDSC balance, associated with a skewing toward type 2 immunity, may predict bladder tumor recurrence and influence the mortality of patients with muscle-invasive cancer. Moreover, these results underline the ILC2/IL-13 axis as a targetable pathway to curtail the M-MDSC compartment and improve bladder cancer treatment

Salvage use of allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning from unrelated donors in multiple myeloma. A study by the Plasma Cell Disorders subcommittee of the European Group for Blood and Marrow Transplant Chronic Malignancies Working Party

Non peer reviewe